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Danazol Suppresses the Production of Interleukin‐1β and Tumor Necrosis Factor by Human Monocytes
Author(s) -
MORI HIDEHIRO,
NAKAGAWA MIKI,
ITOH NAOKI,
WADA KEISUKE,
TAMAYA TERUHIKO
Publication year - 1990
Publication title -
american journal of reproductive immunology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.071
H-Index - 97
eISSN - 1600-0897
pISSN - 1046-7408
DOI - 10.1111/j.1600-0897.1990.tb01037.x
Subject(s) - danazol , interleukin 19 , tumor necrosis factor alpha , tumor necrosis factor α , interleukin , tumor necrosis factors , monocyte , cancer research , necrosis , cytokine , immunology , medicine , endocrinology , biology , microbiology and biotechnology , endometriosis , interleukin 5
The effects of estradiol (E 2 ), progesterone (P), and danazol on the production of interleukin‐1β (IL‐1β) and tumor necrosis factor (TNF) by OK‐432 (a streptococcal preparation)‐stimulated monocytes were examined. E 2 and P at physiologic concentrations enhanced IL‐1β and TNF production by monocytes from donors with lower control levels (without steroids added) of IL‐1β and TNF. However, E 2 and P at physiologic concentrations did not affect IL‐1β and TNF production by monocytes from donors with higher control levels of IL‐1β and TNF. Danazol inhibited IL‐1β and TNF production by monocytes in a dose‐dependent manner from not only donors with lower control levels of IL‐1β and TNF but also donors with higher control levels of IL‐1β and TNF. Danazol at a concentration of 10 −6 M significantly suppressed IL‐1β and TNF production in the presence of E 2 and/or P at concentrations giving peak responses of IL‐1β production. These findings suggest possible new mechanisms of action for danazol in the treatment of endometriosis and infertility associated with immune abnormalities.