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Intradecidual T Lymphocytes Lack Immunohistochemically Detectable T‐Cell Receptors
Author(s) -
DIETL JOHANNES,
HORNY HANSPETER,
RUCK PETER,
MARZUSCH KLAUS,
KAISERLING EDWIN,
GRIESSER HENRIK,
KABELITZ DIETER
Publication year - 1990
Publication title -
american journal of reproductive immunology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.071
H-Index - 97
eISSN - 1600-0897
pISSN - 1046-7408
DOI - 10.1111/j.1600-0897.1990.tb01034.x
Subject(s) - t cell receptor , cd3 , decidua , biology , immunohistochemistry , immune system , receptor , t cell , gamma delta t cell , alpha (finance) , t lymphocyte , beta (programming language) , microbiology and biotechnology , immunology , fetus , cd8 , medicine , pregnancy , placenta , genetics , construct validity , nursing , patient satisfaction , computer science , programming language
The decidua apparently plays a major role in immune tolerance to the semiallogeneic embryo. In the present study we applied the immunohistochemical ABC method to investigate the expression of CD3, TCR α/β and TCR γ/δ molecules on intradecidual T cells with a panel of mAbs. Whereas intradecidual T cells expressed readily detectable amounts of CD3, they lacked immunohistochemically detectable amounts of either α/β or γ/δ TCR heterodimers on their cell surface. Peripheral blood smears of the same patients showed normal expression of α/β and gM/δ TCR on CD3 + T cells. The specific absence of (α/β or γ/δ) TCR molecules on the surface of intradecidual T cells could be one of the decisive factors in tolerance of the maternal immune system towards the fetus.