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Specific Inhibitory Substance to the Husband's HLA Allotype in Sera From Patients With Gestational Trophoblastic Disease Detected by Lymphocytotoxicity Testing
Author(s) -
KATO SENTOYO,
TSUJI KIMIYOSHI,
FURUHASHI YOSHIHITO,
GOTO SETSUKO,
SAITO MITSURU,
TOMODA YUTAKA
Publication year - 1989
Publication title -
american journal of reproductive immunology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.071
H-Index - 97
eISSN - 1600-0897
pISSN - 1046-7408
DOI - 10.1111/j.1600-0897.1989.tb00984.x
Subject(s) - choriocarcinoma , inhibitory postsynaptic potential , titer , gestational trophoblastic disease , chorioepithelioma , human leukocyte antigen , allotype , disease , pregnancy , medicine , immunology , microgram , antibody , monoclonal antibody , abortion , gestation , chemistry , biology , antigen , in vitro , biochemistry , genetics
ABSTRACT: The sera of nine patients with gestational trophoblastic disease were investigated for the inhibitory substance specific to the HLA allotypes of the patients' husbands by microcytoxicity inhibition testing using monoclonal antibodies (anti‐A2, A9, A10) and HLA‐typing serum to Bw52. The specific inhibitory substance was present in three of three choriocarcinoma patients, in three of four invasive mole patients, and in one of two hydatidiform mole patients and seemed to change in titer parallel with tumor growth. These facts suggest that the inhibitory substance could have some relation to the patient's immunological response against the tumor; that is, this inhibitory substance could be the reason why patients could not induce graft rejection response to trophoblastic tumor cells.