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Detection of Immunoregulatory Factors in Retroplacental Serum in Human Pregnancy
Author(s) -
YOSHIDA MASUMI,
KANZAKI HIDEHARU,
TOKUSHIGE MAKOTO,
SATO SHIGEYASU,
KARIYA MASATOSHI,
UCHIDA ATSUSHI,
KASAKURA SHINPEI,
MORI TAKAHIDE
Publication year - 1989
Publication title -
american journal of reproductive immunology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.071
H-Index - 97
eISSN - 1600-0897
pISSN - 1046-7408
DOI - 10.1111/j.1600-0897.1989.tb00564.x
Subject(s) - human placental lactogen , placental lactogen , pregnancy , endocrinology , human chorionic gonadotropin , medicine , glycoprotein , prostaglandin , antibody , prostaglandin e2 , chemistry , biology , andrology , placenta , hormone , immunology , fetus , biochemistry , genetics
Retroplacental serum (RPS) obtained from pregnant women at term deliveries was studied for regulatory effects on T‐lymphocyte proliferation and for pregnancy‐associated substances and compared with peripheral serum (PS) of the same donor. Proliferative response to phytohemagglutinin and alloantigens in RPS was lower than that in PS. RPS contained higher levels of human placental lactogen, progesterone, estradiol, and prostaglandin E 2 than of PS. However, there were no differences in concentrations of pregnancy‐associated α 2 ‐glycoprotein, pregnancy‐specific β 1 ‐glycoprotein, prostaglandin F 2 α, alpha‐fetoprotein, human chorionic gonadotropin, Cortisol, carcinoembryonic antigen, and immunoglobulins between RPS and PS. The amounts of human placental lactogen, progesterone, or prostaglandin E 2 seen in RPS did not inhibit T‐cell proliferation. Mixtures of various doses of these three substances were still not inhibitory. Thus, the suppressive activity of RPS could not be explained by these pregnancy‐associated substances, but a possible involvement of unknown immunoregulatory factors at fetomaternal interface might be suggested.