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Effects of Antibodies Against Chicken Riboflavin Carrier Protein on Fetal Hepatic Cell Ultrastructure
Author(s) -
NATRAJ USHA,
KUMAR R. ASOK
Publication year - 1989
Publication title -
american journal of reproductive immunology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.071
H-Index - 97
eISSN - 1600-0897
pISSN - 1046-7408
DOI - 10.1111/j.1600-0897.1989.tb00540.x
Subject(s) - endoplasmic reticulum , ultrastructure , antibody , fetus , degranulation , glycogen , antiserum , mitochondrion , riboflavin , medicine , chemistry , biology , endocrinology , andrology , biochemistry , immunology , pregnancy , anatomy , genetics , receptor
Day 12 pregnant mice administered antibodies to cRCP exhibited riboflavin deprival, which resulted in progressive alteration in the fetal hepatic cell structure, which eventually led to fetal wastage and termination of pregnancy. These changes were evident as early as 1 h following antiserum treatment. Three hours following treatment, other degenerative changes such as disorganization of glycogen particles and endoplasmic reticulum and degranulation of mitochondria were observed. Nuclear pycnosis, and increased myelin figures, accumulation of lysosomes, all indicative of autolytic changes, occurred 6 h following treatment.