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Distribution of Trop 3 and 4 Antigens in Human Endometrial Glandular Epithelium
Author(s) -
KHONG T.Y.,
SOUBIRAN P.,
HSI B.L.
Publication year - 1988
Publication title -
american journal of reproductive immunology and microbiology
Language(s) - English
Resource type - Journals
eISSN - 1600-0897
pISSN - 8755-8920
DOI - 10.1111/j.1600-0897.1988.tb00184.x
Subject(s) - immunoperoxidase , epithelium , monoclonal antibody , antigen , endometrium , immunohistochemistry , biology , staining , antibody , pathology , immunology , endocrinology , medicine , genetics
The reactivities of three monoclonal antibodies (MAbs), Trop 3, Trop 4, and W6/32, were studied on human uterine tissue by using an indirect immunoperoxidase method. Nonpregnant endometrial glandular epithelium was stained by all three MAbs. During pregnancy, Trop 3 expression was not detectable, but Trop 4 and W6/32 showed variable staining on the endometrial glandular epithelium, especially during late pregnancy. These findings support previous work suggesting a local regulation of antigenic expression by endometrial glandular epithelial cells.