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Immunity to Cytomegalovirus in Women With Unexplained Recurrent Spontaneous Abortion
Author(s) -
RADCLIFFE J.J.,
HART C.A.,
FRANCIS W.J.A.,
JOHNSON P.M.
Publication year - 1986
Publication title -
american journal of reproductive immunology and microbiology
Language(s) - English
Resource type - Journals
eISSN - 1600-0897
pISSN - 8755-8920
DOI - 10.1111/j.1600-0897.1986.tb00073.x
Subject(s) - cytomegalovirus , immunology , herpes simplex virus , antibody , medicine , immunity , abortion , cellular immunity , humoral immunity , lymphocyte , human cytomegalovirus , immune system , virus , herpesviridae , virology , pregnancy , viral disease , biology , genetics
Humoral and cellular immunity to cytomegalovirus (CMV) has been assessed in women suffering unexplained recurrent spontaneous abortions (RSA). A significantly lower prevalence of serum anti‐CMV antibodies was observed for RSA women compared with either their male partners or age‐matched female controls, unlike for serum antibodies to Herpes simplex virus. In addition, there was a markedly impaired lymphocyte proliferative response to CMV for CMV‐sero‐positive RSA women compared with CMV‐seropositive controls. These results indicate that women with unexplained RSA have difficulty in responding to CMV, and are of significance when considering leukocyte transfusion immunotherapy.