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Lymphocyte Subsets in Habitual Abortion
Author(s) -
VIRAG I.,
SCHECTER E.,
ELGAT M.,
ZAKUT H.,
MEYTES D.
Publication year - 1986
Publication title -
american journal of reproductive immunology and microbiology
Language(s) - English
Resource type - Journals
eISSN - 1600-0897
pISSN - 8755-8920
DOI - 10.1111/j.1600-0897.1986.tb00051.x
Subject(s) - abortion , lymphocyte subsets , lymphocyte , immunology , psychology , biology , pregnancy , genetics , immune system , t cell
Lymphocyte subpopulations were characterized by means of monoclonal antibodies in 25 women with habitual abortion and 21 muciparous normal women. Compared to nonpregnant women (N = 8), pregnant normal women were associated with significantly lower helper‐to‐suppressor ratios (1.71 ± 0.41 versus 2.37 ± 0.66). In contrast in pregnant women with habitual abortion (N = 13) the ratio remained high (2.32 ± 0.73). Failure to increase the number of suppressors and a significant rise in helpers caused this increased ratio. We discuss the possible mechanisms and etiological importance of this finding in habitual abortion.