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Uromodulin: An Immunoregulatory Glycoprotein Isolated From Pregnancy Urine That Binds to and Regulates the Activity of Interleukin 1
Author(s) -
MUCHMORE ANDREW V.
Publication year - 1986
Publication title -
american journal of reproductive immunology and microbiology
Language(s) - English
Resource type - Journals
eISSN - 1600-0897
pISSN - 8755-8920
DOI - 10.1111/j.1600-0897.1986.tb00037.x
Subject(s) - tamm–horsfall protein , glycoprotein , urine , pregnancy , chemistry , immunology , microbiology and biotechnology , endocrinology , medicine , biology , biochemistry , genetics
Uromodulin is an 85 kilodalton glycoprotein originally isolated from human pregnancy which has been shown to inhibit antigen specific T cell responses to recall antigens such as tetanus toxoid. We have also found that uromodulin is a high affinity ligand for interleukin 1 and is able to regulate the activity of interleukin 1 in vitro. Finally, we present data that free interleukin 2 receptor can be found in human pregnancy urine. We propose that a number of immunoregulatory phenomena associated with pregnancy are due to molecules able to specifically regulate interleukin 1 and interleukin 2.