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Prostaglandin E 2 and Plasminogen Activators in Human Milk and Their Secretion by Milk Macrophages
Author(s) -
DEIST FRANCOISE LE,
SAINTBASILE GENEVIEVE,
ANGELESCANO EDUARDO,
GRISCELLI CLAUDE
Publication year - 1986
Publication title -
american journal of reproductive immunology and microbiology
Language(s) - English
Resource type - Journals
eISSN - 1600-0897
pISSN - 8755-8920
DOI - 10.1111/j.1600-0897.1986.tb00020.x
Subject(s) - lactation , prostaglandin e2 , secretion , lipopolysaccharide , plasminogen activator , concanavalin a , endocrinology , medicine , chemistry , prostaglandin , activator (genetics) , biology , in vitro , biochemistry , receptor , pregnancy , genetics
Human milk was shown to contain prostaglandin E 2 (PGE 2 ) and plasminogen activator (PA) at variable concentrations depending on the time of lactation after delivery. Milk PA was functionally and immunologically identical to urokinase. A follow‐up study showed that the maximum PGE 2 concentrations occurred during the second week while the maximum PA concentration was observed at the end of the first week of lactation. Milk macrophages cultured in vitro were able to secrete both PGE 2 and PA. When cells were activated by concanavalin A (ConA) or E. coli lipopolysaccharide (LPS), PGE 2 secretion increased dramatically while PA secretion did not. The ability of activated macrophages to secrete PGE 2 was at its highest shortly after delivery. It then progressively decreased during lactation. The possible physiological role of PGE 2 and PA on the gastrointestinal tract of breast fed infants is discussed.