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Effect of H‐2 Complex on the Growth of Embryo‐Derived Teratomas in Mice
Author(s) -
TAYA CHOJI,
MORIWAKI KAZUO
Publication year - 1986
Publication title -
american journal of reproductive immunology and microbiology
Language(s) - English
Resource type - Journals
eISSN - 1600-0897
pISSN - 8755-8920
DOI - 10.1111/j.1600-0897.1986.tb00007.x
Subject(s) - embryo , congenic , biology , teratoma , strain (injury) , mouse strain , locus (genetics) , embryogenesis , genetics , pathology , anatomy , gene , medicine
Seven‐day‐old embryos of several H‐2 congenic strains were transplanted under the kidney capsules of syngeneic adult recipients to determine the genetic factors(s) governing the in vivo growth of embryo‐derived teratomas. A.TH(H‐2 t2 ) and A.TL(H‐2 t1 ) strains showed significantly greater tumor weights than A.BY(H‐2 b ) and A.SW(H‐2 S ) strains. The A(H‐2 a ) strain was intermediate in tumor size. A comparison of the genic constitution of the H‐2 complex in each congenic strain suggested that the H‐2D locus and/or its distal regions affected the growth of embryo‐derived teratomas. The teratoma induced in the B10.A(H‐2 a ) strain was smaller than that in the A(H‐2 a ) strain, indicating that the genetic background of the A strain is favorable for teratoma growth. Histological observations demonstrated that the existence of embryonal carcinoma cells was necessary for the growth of teratomas. A radiation‐sensitive immunological factor in the recipient probably plays a role in stimulating teratoma growth.