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The Mechanism of the Inhibitory Effect of Progesterone on Lymphocyte Cytotoxicity: I. Progesterone‐Treated Lymphocytes Release a Substance Inhibiting Cytotoxicity and Prostaglandin Synthesis
Author(s) -
SZEKERESBARTHO JULIA,
KILAŔ F.,
FALKAY G.,
CSERNUS V.,
TÖRÖK A.,
PACSA A.S.
Publication year - 1985
Publication title -
american journal of reproductive immunology and microbiology
Language(s) - English
Resource type - Journals
eISSN - 1600-0897
pISSN - 8755-8920
DOI - 10.1111/j.1600-0897.1985.tb00334.x
Subject(s) - cycloheximide , cytotoxicity , prostaglandin , lymphocyte , endocrinology , medicine , chemistry , cytotoxic t cell , pharmacology , protein biosynthesis , biochemistry , in vitro
Progesterone‐treated lymphocytes (generator lymphocytes) of healthy pregnant women release a nondialyzable factor that inhibits both cytotoxic activity and prostaglandin F 2 α synthesis of test lymphocytes. Production of this factor is blocked by protein synthesis inhibitors (cycloheximide and actinomycin D). Sodium dodecylsulfate polyacrylamide electrophoresis of the partially purified material revealed a main 34,000 MW protein band. Progesterone‐treated lymphocytes of pregnant women showing clinical symptoms of threatened preterm delivery (risk group) failed to release this substance.