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Immune Monitoring of Pregnancy in Renal Transplanted Patients
Author(s) -
BIRKELAND S.A.,
KRISTOFFERSEN K.
Publication year - 1984
Publication title -
american journal of reproductive immunology
Language(s) - English
Resource type - Journals
eISSN - 1600-0897
pISSN - 0271-7352
DOI - 10.1111/j.1600-0897.1984.tb00292.x
Subject(s) - pregnancy , immune system , medicine , immunology , obstetrics , physiology , intensive care medicine , gynecology , biology , genetics
Immune studies were performed in eight pregnancies occurring after renal transplantation (tx). In three cases a regular, long‐term immune monitoring before, during, and after the pregnancy was possible. The results showed 1) no changes concerning OKT 3, 4, 8, and SMIg‐defined T‐ and B‐lymphocyte subsets in the mothers: 2) a higher level of spontaneous E‐ and normal E‐rosette‐defined T‐subsets in the mothers rejecting their allografts; 3) a stronger response to mitogen and antigen stimulation and a stronger mixed lymphocyte culture (MLC) response towards the infants also in those rejecting their grafts; 4) the offspring of the transplanted mothers showed a weaker immune responder state compared with the offspring of six age‐matched normal mothers.