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Effect of Pregnancy Plasma and Monoclonal Antibodies to HLA and DR Antigens on Leukocyte Migration
Author(s) -
HEGDE UMASHASHI C.,
RAJAN R.,
CHITNIS NISHA D.
Publication year - 1984
Publication title -
american journal of reproductive immunology
Language(s) - English
Resource type - Journals
eISSN - 1600-0897
pISSN - 0271-7352
DOI - 10.1111/j.1600-0897.1984.tb00283.x
Subject(s) - monoclonal antibody , pregnancy , antigen , histocompatibility , human leukocyte antigen , antibody , immunology , fetus , monoclonal , third trimester , andrology , first trimester , medicine , chemistry , endocrinology , biology , genetics
We studied the effect of pregnancy plasma and monoclonal antibodies to the histocompatibility antigens HLA and DR on migration of normal leukocytes from capillaries. It was observed that plasma from women in the first trimester of pregnancy significantly enhanced leukocyte migration at a concentration of 10% (mean area of migration = 50.7 ± 9.2 cm 2 ), as compared with plasma from nonpregnant women (22.8 ± 7.0 cm 2 2; p < 0.05). This effect was less during the second trimester (39.5 ± 3.5 cm 2 ; p < 0.05) and no enhancement was noted with plasma obtained from the third trimester of pregnancy. Similar results were obtained with a 20% concentration of plasma also. On the other hand, the monoclonal anti‐HLA and anti‐DR antibodies had an inhibitory effect on migration of leukocytes. These results are discussed in relation to the immunoregulatory role of pregnancy plasma in the nonrejection of the fetal allograft.