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Sperm Antibodies, Immunoglobulins, and Complement in Human Follicular Fluid
Author(s) -
CLARKE G.N.,
HSIEH C.,
KOH S.H.,
CAUCHI M.N.
Publication year - 1984
Publication title -
american journal of reproductive immunology
Language(s) - English
Resource type - Journals
eISSN - 1600-0897
pISSN - 0271-7352
DOI - 10.1111/j.1600-0897.1984.tb00192.x
Subject(s) - follicular fluid , antibody , sperm , complement (music) , immunology , biology , andrology , medicine , microbiology and biotechnology , oocyte , genetics , embryo , complementation , gene , phenotype
The levels of immunoglobulins (IgG, IgA, IgM), complement (C3, C4, C1EI) and sperm antibodies were determined in plasma and follicular fluid samples from 26 patients undergoing in vitro fertilization (IVF) treatment. The results show that IgG, IgA, C3, C4, and C1EI concentrations in follicular fluid are similar to plasma concentrations (63.1–96.1% of plasma levels). The follicular fluid concentration of IgM was severely reduced, however, being only approximately 10% of plasma concentrations. Sperm antibody titres were compared in three patients using sperm agglutination, immobilization, and immunobead binding. The titres in plasma and follicular fluid were similar, apart from antibodies of IgM class, which were undetectable in follicular fluid.