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Progesterone‐Prostaglandin Balance Influences Lymphocyte Function in Relation to Pregnancy
Author(s) -
SZEKERESBARTHÓ JULIA,
CSERNUS V.,
HADNAGY J.,
PACSA A.S.
Publication year - 1983
Publication title -
american journal of reproductive immunology
Language(s) - English
Resource type - Journals
eISSN - 1600-0897
pISSN - 0271-7352
DOI - 10.1111/j.1600-0897.1983.tb00268.x
Subject(s) - cytotoxic t cell , prostaglandin , endocrinology , medicine , pregnancy , lymphocyte , prostaglandin e1 , prostaglandin d2 , prostaglandin e2 , chemistry , biology , in vitro , biochemistry , genetics
The effect of progesterone and prostglandin F 2 α on cytotoxic activity of lymphocytes was investigated. Thirty‐three pregnant women with a clinical diagnosis of threatened premature labour were treated with the prostaglandin synthesis inhibitor acetylsalicylic acid (2.7 gm/day) for 1 week. Cytotoxic activity of the lymphocytes significantly decreased while their progesterone binding capacity increased by the end of the treatment. Ten healthy pregnant women received a single 15 mg dose of prostaglandin F 2 α for pregnancy termination. One day after prostaglandin administration lymphocytes showed significantly higher cytotoxic activity and lower progesterone binding capacity than before. Lymphocytes of 44 healthy nonpregnant volunteers were preincubated with prostaglandin F 2 α and/or progesterone. Prostaglandin F 2 α (8 nmole) significantly decreased cytotoxic activity of 4 × 10 6 lymphocytes. In the presence of progesterone prostaglandin F 2 α failed to stimulate lymphocytes.