Premium
The Identification of Suppressor Cells in the Murine Fetal Liver *
Author(s) -
MAIN ELLIOTT K.,
PIERCE CARL W.
Publication year - 1983
Publication title -
american journal of reproductive immunology
Language(s) - English
Resource type - Journals
eISSN - 1600-0897
pISSN - 0271-7352
DOI - 10.1111/j.1600-0897.1983.tb00232.x
Subject(s) - suppressor , immune system , fetus , biology , mixed lymphocyte reaction , immunology , population , cell , immune tolerance , heterologous , t cell , microbiology and biotechnology , pregnancy , genetics , medicine , gene , environmental health
Fetal suppressor cells are potentially important for maintenance of pregnancy and for the immune regulation of the identification of self. We have identified and partially characterized a population of murine fetal liver cells which are active suppressors of a variety of immune responses, including mixed lymphocyte responses (MLR), responses to mitogens plaque‐forming cell responses to heterologous erythrocytes. The suppression is non‐H‐2‐restricted and can act via a factor. The cell is preactivated in fetal liver and may represent a T‐cell precursor. The suppression of MLR is maximal (approximately 100%) if cells are added within the first 48 h of culture initiation. The characteristics of this suppressor cell are compared to other known MLR and perinatal suppressor systems.