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Epstein‐Barr Virus in Normal Pregnant Women *
Author(s) -
SAKAMOTO KIYOSHI,
GREALLY JOHN,
GILFILLAN ROBERT F.,
SEXTON JULIANNE,
BARNABEI VANESSA,
YETZ JOANNE,
BECHTOLD THOMAS,
SEELEY JANET K.,
O'DWYER EAMON,
PURTILO DAVID T.
Publication year - 1982
Publication title -
american journal of reproductive immunology
Language(s) - English
Resource type - Journals
eISSN - 1600-0897
pISSN - 0271-7352
DOI - 10.1111/j.1600-0897.1982.tb00169.x
Subject(s) - cytomegalovirus , virus , antibody , virology , capsid , titer , rubella virus , pregnancy , antigen , immunology , rubella , herpesviridae , antibody titer , medicine , immune system , biology , viral disease , vaccination , measles , genetics
Acquired immune suppression accompanying normal pregnancy may be associated with reactivation of Epstein‐Barr virus (EBV). Pregnant women with reactivated EBV having anti‐EA antibodies show high titers of antiviral capsid antigen (VCA) geometric mean titers (GMT) of 522 versus 170 in those lacking anti‐early antigen (EA). Among twenty‐seven seropositive women at parturition, 17 (63%) had generated antibody to EA, and all 27 (100%) demonstrated significant increases in antibody to VCA (p < 0.01). In contrast, antibody titers to cytomegalovirus, herpes hominis, varicella‐zoster, and rubella viruses in the pregnant women were comparable to those found in nonpregnant controls.