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Lymphocyte Specificity to Protein Antigens. IV. In Vivo and In Vitro Activation of Cytochrome‐Specific T Cells Is Dependent on Protein Conformation *
Author(s) -
CORRADIN GIAMPIETRO,
CHILLER JACQUES M.,
ENGERS HOWARD D.,
BRON CLAUDE,
BÜCHMULLER YOLANDE
Publication year - 1981
Publication title -
american journal of reproductive immunology
Language(s) - English
Resource type - Journals
eISSN - 1600-0897
pISSN - 0271-7352
DOI - 10.1111/j.1600-0897.1981.tb00065.x
Subject(s) - cytochrome c , in vitro , cytochrome , in vivo , antigen , population , biology , t lymphocyte , microbiology and biotechnology , biochemistry , chemistry , immunology , mitochondrion , genetics , enzyme , medicine , environmental health
Data are presented that suggest that the activation of cytochrome c‐specific T lymphocytes is dependent on the integrity of the three‐dimensional structure of the protein antigen. These results were obtained both at the population level and at the clonal level. The capacity of the native and denatured forms of cytochrome c to activate a different set of T cell clones was observed both in vivo and in vitro. These results could be explained by the differential capacity of macrophages to process and/or present the two forms of cytochrome c .