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Absence of T Cell‐Mediated Cytotoxicity in Breast Cancer Patients Against A Breast Cancer‐Derived Target Cell
Author(s) -
ILIESCU VIRGINIA,
FITZHARRIS PENNY,
KNIGHT R.A.,
SOUHAMI R.L.,
ENGLAND P.
Publication year - 1981
Publication title -
american journal of reproductive immunology
Language(s) - English
Resource type - Journals
eISSN - 1600-0897
pISSN - 0271-7352
DOI - 10.1111/j.1600-0897.1981.tb00060.x
Subject(s) - breast cancer , cytotoxic t cell , cytotoxicity , cell , cancer research , cancer , medicine , sensitization , immunology , rosette (schizont appearance) , antigen , human leukocyte antigen , oncology , biology , in vitro , biochemistry , genetics
Fresh E‐rosette positive lymphocytes from normal donors are not cytotoxic for the breast cancer‐derived target cell MDA‐157, although they do lyse other suspension and monolayer targets. E‐rosette positive cells from breast cancer patients in different stages of disease and from patients with benign breast disease also do not lyse MDA‐157. This remains true even when an HLA‐A or ‐B locus antigen is shared by effector and target cell. These data therefore provide no evidence for T cell sensitization in breast cancer patients.