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Effect of Betamethasone on Fetal Macrophage Function: Depression of Adherence of Immunoglobulin‐Coated Red Blood Cells
Author(s) -
CAUDLE MICHAEL R.,
HARBERT GUY M.,
SINGHAS CHARLES A.
Publication year - 1981
Publication title -
american journal of reproductive immunology
Language(s) - English
Resource type - Journals
eISSN - 1600-0897
pISSN - 0271-7352
DOI - 10.1111/j.1600-0897.1981.tb00033.x
Subject(s) - betamethasone , immune system , fetus , antibody , in vivo , endocrinology , macrophage , immunology , in vitro , depression (economics) , medicine , pregnancy , chemistry , andrology , biology , biochemistry , microbiology and biotechnology , macroeconomics , economics , genetics
In this study, betamethasone was found to significantly inhibit the binding of immunoglobulin‐coated O Rh‐positive red cells to fetal macrophages. At a dose of 0.15 mg%, betamethasone depressed immune rosette formation to 44% of controls (p < 0.01); and a dose of 0.60 mg% resulted in an average depression to 22%. This in vitro effect may reflect important alterations in in vivo immune function in infants delivered from mothers who have received antenatal corticosteroids.