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The DSL1 Complex: The Smallest but Not the Least CATCHR
Author(s) -
Spang Anne
Publication year - 2012
Publication title -
traffic
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.677
H-Index - 130
eISSN - 1600-0854
pISSN - 1398-9219
DOI - 10.1111/j.1600-0854.2012.01362.x
Subject(s) - tethering , copi , biology , vesicular transport proteins , microbiology and biotechnology , endoplasmic reticulum , golgi apparatus , endocytic cycle , endosome , secretory pathway , biochemistry , endocytosis , cell , vacuolar protein sorting , intracellular
The DSL1 complex is a conserved tethering complex at the endoplasmic reticulum that recognizes Golgi-derived COPI vesicles and hands them over to the fusion machinery. The DSL1 complex is the simplest tethering complex of the complexes associated with tethering containing helical rods (CATCHR) family. CATCHR tethering complexes play a role at compartments along the exocytic and endocytic pathways. In this review, different functions of the DSL1 complex are discussed, some open questions with the seemingly straightforward picture are pointed out and alternative functions of the DSL1 complex members are mentioned.