Premium
Secretive Bacterial Pathogens and the Secretory Pathway
Author(s) -
Hilbi Hubert,
Haas Albert
Publication year - 2012
Publication title -
traffic
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.677
H-Index - 130
eISSN - 1600-0854
pISSN - 1398-9219
DOI - 10.1111/j.1600-0854.2012.01344.x
Subject(s) - biology , endomembrane system , effector , endocytic cycle , microbiology and biotechnology , secretory pathway , intracellular , intracellular parasite , secretion , microvesicles , endoplasmic reticulum , golgi apparatus , cell , genetics , biochemistry , gene , endocytosis , microrna
Eukaryotic cells possess two extensive endomembrane systems, each consisting of several sub-compartments connected by vesicular trafficking. One of these systems, the endocytic pathway, serves incoming traffic, and the other system, the secretory pathway (SP), is responsible for surface-bound traffic of intracellularly formed vesicles. Compartments derived of either system can be colonized by intracellular pathogens. In this review, we discuss the interactions between the SP and prominent intracellular bacterial pathogens of the genera Legionella, Brucella, Chlamydia and Salmonella. We emphasize secreted bacterial effector proteins, which directly manipulate host components of this pathway.