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Regulation of Vps4 During MVB Sorting and Cytokinesis
Author(s) -
Babst Markus,
Davies Brian A.,
Katzmann David J.
Publication year - 2011
Publication title -
traffic
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.677
H-Index - 130
eISSN - 1600-0854
pISSN - 1398-9219
DOI - 10.1111/j.1600-0854.2011.01230.x
Subject(s) - escrt , endosome , cytokinesis , microbiology and biotechnology , biology , tsg101 , transport protein , aaa proteins , transmembrane protein , atpase , cell division , biochemistry , intracellular , cell , microvesicles , microrna , receptor , gene , enzyme
Multivesicular body (MVB) formation is the result of invagination and budding of the endosomal limiting membrane into its intralumenal space. These intralumenal vesicles (ILVs) contain a subset of endosomal transmembrane cargoes destined for degradation within the lysosome, the result of active selection during MVB sorting. Membrane bending and scission during ILV formation is topologically similar to cytokinesis in that both events require the abscission of a membrane neck that is oriented away from the cytoplasm. The endosomal sorting complexes required for transport (ESCRTs) represent cellular machinery whose function makes essential contributions to both of these processes. In particular, the AAA‐ATPase Vps4 and its substrate ESCRT‐III are key components that seem to execute the membrane abscission reaction. This review summarizes current knowledge about the Vps4‐ESCRT‐III system and discusses a model for how the recruitment of Vps4 to the different sites of function might be regulated.