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Molecular Mechanism of Co‐translational Protein Targeting by the Signal Recognition Particle
Author(s) -
Saraogi Ishu,
Shan Shuou
Publication year - 2011
Publication title -
traffic
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.677
H-Index - 130
eISSN - 1600-0854
pISSN - 1398-9219
DOI - 10.1111/j.1600-0854.2011.01171.x
Subject(s) - signal recognition particle , biology , microbiology and biotechnology , mechanism (biology) , protein targeting , signal recognition particle receptor , computational biology , protein sorting signals , transport protein , membrane protein , signal peptide , membrane , genetics , gene , peptide sequence , physics , quantum mechanics
The signal recognition particle (SRP) is a key component of the cellular machinery that couples the ongoing synthesis of proteins to their proper localization, and has often served as a paradigm for understanding the molecular basis of protein localization within the cell. The SRP pathway exemplifies several key molecular events required for protein targeting to cellular membranes: the specific recognition of signal sequences on cargo proteins, the efficient delivery of cargo to the target membrane, the productive unloading of cargo to the translocation machinery and the precise spatial and temporal coordination of these molecular events. Here we highlight recent advances in our understanding of the molecular mechanisms underlying this pathway, and discuss new questions raised by these findings.