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Emerging Roles of Ruk/CIN85 in Vesicle‐Mediated Transport, Adhesion, Migration and Malignancy
Author(s) -
Havrylov Serhiy,
Jolanta Redowicz Maria,
Buchman Vladimir L.
Publication year - 2010
Publication title -
traffic
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.677
H-Index - 130
eISSN - 1600-0854
pISSN - 1398-9219
DOI - 10.1111/j.1600-0854.2010.01061.x
Subject(s) - biology , signal transducing adaptor protein , microbiology and biotechnology , cancer cell , vesicular transport protein , cancer , signal transduction , cytoskeleton , cell , vesicle , genetics , membrane
Ruk/CIN85 is an adaptor protein. Similar to many other proteins of this type, Ruk/CIN85 is known to take part in multiple cellular processes including signal transduction, vesicle‐mediated transport, cytoskeleton remodelling, programmed cell death and viral infection. Recent studies have also revealed the potential importance of Ruk/CIN85 in cancer cell invasiveness. In this review we summarize the various roles of this protein as well as the potential contribution of Ruk/CIN85 to malignancy and the invasiveness of cancer cells. In the last section of the paper we also speculate on the utility of Ruk/CIN85 as a target for novel anti‐cancer therapies.