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Messenger RNA Export from the Nucleus: A Series of Molecular Wardrobe Changes
Author(s) -
Kelly Seth M.,
Corbett Anita H.
Publication year - 2009
Publication title -
traffic
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.677
H-Index - 130
eISSN - 1600-0854
pISSN - 1398-9219
DOI - 10.1111/j.1600-0854.2009.00944.x
Subject(s) - biology , messenger rna , microbiology and biotechnology , nuclear export signal , cytoplasm , nucleus , rna , transcription (linguistics) , biogenesis , cell nucleus , ribosome biogenesis , ribosome , genetics , gene , linguistics , philosophy
The advent of the nucleus during the evolutionary development of the eukaryotic cell necessitated the development of a transport system to convey messenger RNA (mRNA) from the site of transcription in the nucleus to ribosomes in the cytoplasm. In this review, we highlight components of each step in mRNA biogenesis, from transcription to processing, that are coupled with mRNA export from the nucleus. We also review the mechanism by which proteins from one step in the mRNA assembly line are replaced by those required for the next. These ‘molecular wardrobe changes' appear to be key steps in facilitating the rapid and efficient nuclear export of mRNA transcripts.