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Defining Macropinocytosis
Author(s) -
Kerr Markus C.,
Teasdale Rohan D.
Publication year - 2009
Publication title -
traffic
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.677
H-Index - 130
eISSN - 1600-0854
pISSN - 1398-9219
DOI - 10.1111/j.1600-0854.2009.00878.x
Subject(s) - pinocytosis , endocytic cycle , biology , endocytosis , microbiology and biotechnology , immune system , antigen presentation , cell , immunology , t cell , genetics
Macropinocytosis represents a distinct pathway of endocytosis in mammalian cells. This actin‐driven endocytic process is not directly co‐ordinated by the presence of cargo but can be induced upon activation of growth factor signalling pathways. The capacity to dissect the contribution of macropinocytosis to cellular processes has been hampered by a lack of unique molecular markers and defining features. While aspects of macropinosome formation and maturation are common to those shared by the other endocytic pathways, a number of key differences have recently begun to emerge and will be discussed in this study. It is now well established that macropinocytosis significantly contributes to antigen presentation by the immune system and is exploited by a range of pathogens for cellular invasion and avoidance of immune surveillance.