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Secretory Outposts for the Local Processing of Membrane Cargo in Neuronal Dendrites
Author(s) -
Hanus Cyril,
Ehlers Michael D.
Publication year - 2008
Publication title -
traffic
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.677
H-Index - 130
eISSN - 1600-0854
pISSN - 1398-9219
DOI - 10.1111/j.1600-0854.2008.00775.x
Subject(s) - postsynaptic potential , biology , organelle , microbiology and biotechnology , dendrite (mathematics) , synapse , neuroscience , biochemistry , geometry , receptor , mathematics
The large size and geometric complexity of neuronal dendrites necessitate specialized mechanisms to both deliver postsynaptic cargo over extended distances and regulate dendritic composition on a submicron scale. Despite the fundamental importance of membrane trafficking in dendrite growth, synapse formation and plasticity, the organelles and cellular rules governing postsynaptic trafficking are only now emerging. Here we review what is currently known about dendritic secretory organelles and their role in the development, maintenance and plasticity of postsynaptic compartments.