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Apicomplexa in Mammalian Cells: Trafficking to the Parasitophorous Vacuole
Author(s) -
CesbronDelauw MarieFrance,
Gendrin Claire,
Travier Laetitia,
Ruffiot Pauline,
Mercier Corinne
Publication year - 2008
Publication title -
traffic
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.677
H-Index - 130
eISSN - 1600-0854
pISSN - 1398-9219
DOI - 10.1111/j.1600-0854.2008.00728.x
Subject(s) - biology , apicomplexa , microbiology and biotechnology , cytoplasm , vacuole , compartmentalization (fire protection) , protein targeting , plasmodium (life cycle) , parasite hosting , membrane protein , genetics , plasmodium falciparum , immunology , membrane , biochemistry , enzyme , malaria , world wide web , computer science
Most Apicomplexa reside and multiply in the cytoplasm of their host cell, within a parasitophorous vacuole (PV) originating from both parasite and host cell components. Trafficking of parasite‐encoded proteins destined to membrane compartments beyond the confine of the parasite plasma membrane is a process that offers a rich territory to explore novel mechanisms of protein–membrane interactions. Here, we focus on the PVs formed by the asexual stages of two pathogens of medical importance, Plasmodium and Toxoplasma . We compare the PVs of both parasites, with a particular emphasis on their evolutionary divergent compartmentalization within the host cell. We also discuss the existence of peculiar export mechanisms and/or sorting determinants that are potentially involved in the post‐secretory targeting of parasite proteins to the PV subcompartments.