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Secretion of Proteins into Host Cells by Apicomplexan Parasites
Author(s) -
Ravindran Sandeep,
Boothroyd John C.
Publication year - 2008
Publication title -
traffic
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.677
H-Index - 130
eISSN - 1600-0854
pISSN - 1398-9219
DOI - 10.1111/j.1600-0854.2008.00723.x
Subject(s) - biology , obligate , apicomplexa , secretion , plasmodium (life cycle) , intracellular parasite , parasite hosting , host (biology) , obligate parasite , intracellular , microbiology and biotechnology , protozoa , plasmodium falciparum , genetics , malaria , ecology , immunology , biochemistry , world wide web , computer science
The phylum Apicomplexa consists of a diverse group of obligate, intracellular parasites. The distinct evolutionary pressures on these protozoans as they have adapted to their respective niches have resulted in a variety of methods that they use to interact with and modify their hosts. One of these is the secretion and trafficking of parasite proteins into the host cell. We review this process for Theileria , Toxoplasma and Plasmodium . We also present what is known about the mechanisms by which parasite proteins are exported into the host cell, as well as information on their known and putative functions once they have reached their final destination.