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Protein Transport Across the Parasitophorous Vacuole of Plasmodium falciparum : Into the Great Wide Open
Author(s) -
Charpian Stefan,
Przyborski Jude M.
Publication year - 2008
Publication title -
traffic
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.677
H-Index - 130
eISSN - 1600-0854
pISSN - 1398-9219
DOI - 10.1111/j.1600-0854.2007.00648.x
Subject(s) - biology , plasmodium falciparum , vacuole , parasite hosting , microbiology and biotechnology , cytosol , transport protein , plasmodium (life cycle) , malaria , biochemistry , immunology , cytoplasm , world wide web , computer science , enzyme
The human malaria parasite Plasmodium falciparum resides and multiplies within a membrane‐bound vacuole in the cytosol of its host cell, the mature human erythrocyte. To enable the parasite to complete its intraerythrocytic life cycle, a large number of parasite proteins are synthesized and transported from the parasite to the infected cell. To gain access to the erythrocyte, parasite proteins must first cross the membrane of the parasitophorous vacuole (PVM), a process that is not well understood at the mechanistic level. Here, we review past and current literature on this topic, and make tentative predictions about the nature of the transport machinery required for transport of proteins across the PVM, and the molecular factors involved.