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Migration Cues Induce Chromatin Alterations
Author(s) -
Gerlitz Gabi,
Livnat Idit,
Ziv Carmit,
Yarden Oded,
Bustin Michael,
Reiner Orly
Publication year - 2007
Publication title -
traffic
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.677
H-Index - 130
eISSN - 1600-0854
pISSN - 1398-9219
DOI - 10.1111/j.1600-0854.2007.00638.x
Subject(s) - biology , chromatin , microbiology and biotechnology , histone h1 , histone , chromatin remodeling , histone h3 , heterochromatin , histone code , nucleosome , epigenetics , multicellular organism , histone h4 , cell , genetics , dna , gene
Directed cell migration is a property central to multiple basic biological processes. Here, we show that directed cell migration is associated with global changes in the chromatin fiber. Polarized posttranslational changes in histone H1 along with a transient decrease in H1 mobility were detected in cells facing the scratch in a wound healing assay. In parallel to the changes in H1, the levels of the heterochromatin marker histone H3 lysine 9 tri‐methylation were elevated. Interestingly, reduction of the chromatin‐binding affinity of H1 altered the cell migration rates. Moreover, migration‐associated changes in histone H1 were observed during nuclear motility in the simple multicellular organism Neurospora crassa . Our studies suggest that dynamic reorganization of the chromatin fiber is an early event in the cellular response to migration cues.