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Processing and Assembly of the Dystrophin Glycoprotein Complex
Author(s) -
Allikian Michael J.,
McNally Elizabeth M.
Publication year - 2007
Publication title -
traffic
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.677
H-Index - 130
eISSN - 1600-0854
pISSN - 1398-9219
DOI - 10.1111/j.1600-0854.2006.00519.x
Subject(s) - sarcolemma , microbiology and biotechnology , biology , myofibril , dystrophin , cytoskeleton , dystroglycan , skeletal muscle , itga7 , glycoprotein , myocyte , membrane protein , extracellular matrix , anatomy , biochemistry , cell , membrane , laminin
The assembly, processing and translocation of proteins occur constantly in all cells, and these processes also take place during the genesis, maintenance and repair of skeletal muscle. Skeletal muscle fibers are composed of myofibrils and are surrounded by a muscle plasma membrane, the sarcolemma. The sarcolemma serves as a docking location for many proteins. These proteins are important for establishing the physical connection between the extracellular matrix and the cytoskeleton and play a role in transmitting force related to muscle contraction. This physical connection is maintained through a myriad of proteins including the dystrophin glycoprotein complex (DGC). Normal sarcolemmal function requires proper DGC synthesis and positioning, and perturbation of the DGC leads to muscle membrane instability and disease.