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Keep the Traffic Moving: Mechanism of the Hsp70 Motor
Author(s) -
Sousa Rui,
Lafer Eileen M.
Publication year - 2006
Publication title -
traffic
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.677
H-Index - 130
eISSN - 1600-0854
pISSN - 1398-9219
DOI - 10.1111/j.1600-0854.2006.00497.x
Subject(s) - biology , atp hydrolysis , clathrin , microbiology and biotechnology , organelle , hsp70 , motor protein , transport protein , molecular motor , mechanism (biology) , vesicle , biophysics , biochemistry , heat shock protein , microtubule , enzyme , atpase , membrane , philosophy , epistemology , gene
Hsp70s are ubiquitous chaperones that use ATP hydrolysis to drive a variety of protein processing reactions, including a number of steps in protein trafficking. Recent studies have shed light on how ATP might generate conformational changes in an Hsp70 molecule and how such changes might be harnessed to drive processes as diverse as protein import into subcellular organelles and uncoating of clathrin‐coated vesicles.