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Nuclear Translocation of Cell‐Surface Receptors: Lessons from Fibroblast Growth Factor
Author(s) -
Bryant David M.,
Stow Jennifer L.
Publication year - 2005
Publication title -
traffic
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.677
H-Index - 130
eISSN - 1600-0854
pISSN - 1398-9219
DOI - 10.1111/j.1600-0854.2005.00332.x
Subject(s) - biology , microbiology and biotechnology , fibroblast growth factor , cell surface receptor , fibroblast growth factor receptor , epidermal growth factor , nuclear transport , cell nucleus , signal transduction , nuclear protein , receptor , nucleus , genetics , transcription factor , gene
The nuclear localization of a number of growth factors, cytokine ligands and their receptors has been reported in various cell lines and tissues. These include members of the fibroblast growth factor (FGF), epidermal growth factor and growth hormone families. Accordingly, a number of nuclear functions have begun to emerge for these protein families. The demonstration of functional interactions of these proteins with the nuclear import machinery has further supported their functions as nuclear signal transducers. Here, we review the membrane‐ trafficking machinery and pathways demonstrated to regulate this cell surface to nucleus‐trafficking event and highlight the many remaining unanswered questions. We focus on the FGF family, which is providing many of the clues as to the process of this unusual phenomenon.