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Protein Targeting from Malaria Parasites to Host Erythrocytes
Author(s) -
Römisch Karin
Publication year - 2005
Publication title -
traffic
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.677
H-Index - 130
eISSN - 1600-0854
pISSN - 1398-9219
DOI - 10.1111/j.1600-0854.2005.00310.x
Subject(s) - biology , plasmodium falciparum , malaria , obligate , intracellular parasite , parasite hosting , host (biology) , plasmodium (life cycle) , intracellular , transmembrane protein , obligate parasite , microbiology and biotechnology , apicomplexa , protozoa , virology , immunology , genetics , ecology , receptor , world wide web , computer science
Malaria is caused by obligate intracellular parasites, which live in host erythrocytes and remodel these cells to provide optimally for their own needs. Plasmodium falciparum , responsible for malaria in humans, transports many proteins into erythrocytes which help the parasite survive in the host. The recent discovery of a host cell‐targeting sequence present in both soluble and transmembrane P. falciparum proteins provoked a discussion on the potential mechanisms of parasite protein entry into infected erythrocytes which is summarized here.