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Construction of Centrosomes and Spindle Poles by Molecular Motor‐Driven Assembly of Protein Particles
Author(s) -
Zimmerman Wendy,
Doxsey Stephen J.
Publication year - 2000
Publication title -
traffic
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.677
H-Index - 130
eISSN - 1600-0854
pISSN - 1398-9219
DOI - 10.1111/j.1600-0854.2000.11202.x
Subject(s) - centrosome , biology , microbiology and biotechnology , microtubule , spindle pole body , mitosis , dynein , spindle apparatus , organelle , astral microtubules , motor protein , interphase , microtubule organizing center , cytoplasm , cell division , dynactin , molecular motor , cell , genetics , cell cycle
Centrosomes and other microtubule organizing centers are the largest non‐membranous organelles in most cells. This morphologically diverse class of organelles shares a common ability to nucleate and organize microtubules in interphase and participates in the formation of mitotic spindles during cell division. This review summarizes recent evidence suggesting that assembly of centrosomes and mitotic spindle poles require transport of large protein particles along microtubules by the molecular motor cytoplasmic dynein.