Open AccessPatterns of aluminum hydroxychloride deposition onto the skin
Author(s) -
Mayeux Géraldine,
XhauflaireUhoda Emmanuelle,
Piérard Gérald E.
Publication year - 2012
Publication title -
skin research and technology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.521
H-Index - 69
eISSN - 1600-0846
pISSN - 0909-752X
DOI - 10.1111/j.1600-0846.2011.00532.x
Subject(s) - stratum corneum , transepidermal water loss , deposition (geology) , chemistry , biomedical engineering , dermatology , pathology , medicine , geology , sediment , paleontology
Background: Aluminum hydroxychloride (AlCl 3 ) is an antiperspirant.Aim: To revisit the AlCl 3 deposition in vivo and in vitro on glass slides and stratum corneum (SC) harvested by cyanoacrylate skin surface strippings (CSSS).Methods: Transepidermal water loss (TEWL) was assessed following application of 5% AlCl 3 on the forearms. The AlCl 3 ‐coated skin, glass slides and CSSS were observed using two ultraviolet light‐emitting CCD cameras in order to record changes in specular reflectance related to AlCl 3 deposition. In addition, the corneoxenometry bioassay was performed in order to predict AlCl 3 irritation.Results: AlCl 3 deposited on glass slides looked as linear threads and rings of similar sizes. AlCl 3 deposits on skin were almost restricted inside the microrelief lines and as annular deposits at their crossings where acrosyringia are opening. After daily AlCl 3 applications, deposits extended on the CSSS plateaus. At rest in absence of sweating, TEWL was decreased following AlCl 3 applications. During physical exercise, the TEWL increase was limited on the AlCl 3 areas. CSSS appeared unreactive to AlCl 3 at the corneoxenometry bioassay.Conclusion: The similar aspect of AlCl 3 deposits on human SC and on glass slides suggested a physical property of AlCl 3 . Repetitive applications of AlCl 3 increased both the deposit area and the barrier function.