Evaluation of allergic vesicular reaction to patch test using  in vivo  confocal microscopy | Zendy

Ardigò Marco | Zendy; Longo Caterina | Zendy; Cristaudo Antonio | Zendy; Berardesca Enzo | Zendy; Pellacani Giovanni | Zendy

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Evaluation of allergic vesicular reaction to patch test using in vivo confocal microscopy

Author(s) -

Ardigò Marco,

Longo Caterina,

Cristaudo Antonio,

Berardesca Enzo,

Pellacani Giovanni

Publication year - 2012

Publication title -

skin research and technology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.521

H-Index - 69

eISSN - 1600-0846

pISSN - 0909-752X

DOI - 10.1111/j.1600-0846.2011.00531.x

Subject(s) - confocal microscopy , confocal , microscopy , in vivo , pathology , medicine , chemistry , biology , optics , microbiology and biotechnology , physics

Background: Confocal microscopy has been successfully applied both in oncologic and inflammatory diseases. In particular, it has been proved as a useful tool for the in vivo detection of microscopical changes occurring in allergic reactions.Aims of the study: To evaluate microscopic changes occurring in positive patch test reactions.Methods: Eight patients with history of allergic dermatitis and positive patch test reaction were analysed by means of confocal microscopy.Results: Confocal microscopy showed the presence of spongiotic vesicle preferentially localized around the adnexal ducts that appeared to be in the middle of the spongiotic phenomena.Conclusion: Confocal microscopy offered for the first time new insight into vesicle formation and development, showing that adnexal ducts can play a role in allergic reaction.

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