Open AccessPorcine ear skin: an in vitro model for human skin
Author(s) -
Jacobi Ute,
Kaiser Marco,
Toll Rani,
Mangelsdorf Susanne,
Audring Heike,
Otberg Nina,
Sterry Wolfram,
Lademann Juergen
Publication year - 2007
Publication title -
skin research and technology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.521
H-Index - 69
eISSN - 1600-0846
pISSN - 0909-752X
DOI - 10.1111/j.1600-0846.2006.00179.x
Subject(s) - stratum corneum , human skin , cyanoacrylate , penetration (warfare) , anatomy , epidermis (zoology) , biomedical engineering , pathology , chemistry , materials science , medicine , biology , nanotechnology , genetics , adhesive , layer (electronics) , operations research , engineering
Background/purpose: Porcine ear skin is used in studies of percutaneous penetration as a substitute for human skin. The structure of this tissue, including hair follicles, was studied qualitatively and quantitatively in comparison with human skin. Methods: Sections of shock‐frozen biopsies, biopsies embedded in paraffin and cyanoacrylate skin surface biopsies were investigated using microscopy. The thickness of the different skin layers and the follicular characteristics were determined. Results: The thickness of the stratum corneum was 17–28 μm, whereas the viable epidermis was 60–85 μm thick. On 1 cm 2 , 11–25 hairs were detected, showing a diameter of 58–97 μm and a maximal extension depth of 0.96–1.38 mm into the skin. The orifices of the porcine infundibula showed a diameter of approximately 200 μm. Conclusions: The results obtained are similar to those of human skin, indicating the suitability of this porcine tissue as a model for human skin.