Open AccessBarrier repair in chronic plaque‐type psoriasis
Author(s) -
Goon Anthony TeikJin,
Yosipovitch Gil,
Chan YiongHuak,
Goh CheeLeok
Publication year - 2004
Publication title -
skin research and technology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.521
H-Index - 69
eISSN - 1600-0846
pISSN - 0909-752X
DOI - 10.1111/j.1600-0846.2004.00046.x
Subject(s) - transepidermal water loss , psoriasis , medicine , dermatology , skin barrier , barrier function , significant difference , basal (medicine) , pathology , mathematical optimization , mathematics , stratum corneum , insulin
Purpose: To investigate barrier repair after mild trauma in lesional skin of psoriasis patients with chronic plaque‐type disease and to compare this with non‐involved psoriatic skin and normal controls. Methods: Transepidermal water loss (TEWL) readings were taken from involved psoriatic skin and non‐involved skin of psoriasis patients as well as the skin of normal controls. Three readings were performed at each site: the basal state, immediately after 20 tape strippings and 1 week post stripping. Results: Higher baseline, post‐stripping and 1‐week recovery TEWL readings in psoriatic‐involved skin compared to non‐involved and normal control skin. No significant difference in barrier recovery rate in psoriatic‐involved skin compared to non‐involved and normal control. Conclusion: Although there appears to be a derangement of barrier function in lesional skin of psoriasis patients compared to non‐lesional skin and the skin of healthy controls, the barrier recovery function of lesional psoriatic skin is still fully operational.