Open AccessOpen application assay in investigation of subclinical irritant dermatitis induced by sodium lauryl sulfate (SLS) in man: advantage of squamometry
Author(s) -
Charbonnier Veranne,
Morrison Boyce M.,
Paye Marc,
Maibach Howard I.
Publication year - 1998
Publication title -
skin research and technology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.521
H-Index - 69
eISSN - 1600-0846
pISSN - 0909-752X
DOI - 10.1111/j.1600-0846.1998.tb00117.x
Subject(s) - irritation , subclinical infection , skin irritation , pulmonary surfactant , dermatology , dryness , irritant contact dermatitis , eye irritation , medicine , contact dermatitis , chemistry , surgery , pathology , allergy , immunology , biochemistry
Background/aims: After a single occlusive application (24 h patch test), SLS can cause irritation, dryness, and tightness. In typical use, clinical surfactant exposure is usually brief, of open application, and cumulative. The open application model becomes relevant when phenomena, such as dryness and subclinical, i.e., non‐visible, irritation are induced. Methods: Exaggerated hand wash was performed in a total of 21 healthy individuals. Signs of skin irritation were scored, and skin reactions were measured using various bioengineering techniques. Results: These studies demonstrate that an exaggerated hand wash model permits exploration of sub‐clinical irritation. Conclusions: Squamometry proved to be a sensitive, complementary method to detect surfactant‐induced, sub‐clinical skin alterations.