Open AccessPhosphorus metabolites in human skin and muscle obtained by phosphorus‐31 magnetic resonance spectroscopy
Author(s) -
Wright A. C.,
Bohning D. E.,
Spicer K. M.
Publication year - 1997
Publication title -
skin research and technology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.521
H-Index - 69
eISSN - 1600-0846
pISSN - 0909-752X
DOI - 10.1111/j.1600-0846.1997.tb00163.x
Subject(s) - phosphocreatine , metabolite , chemistry , phosphodiester bond , phosphorus , nuclear magnetic resonance spectroscopy , spectroscopy , in vivo , inorganic phosphate , phosphate , human skin , creatine , biochemistry , energy metabolism , medicine , biology , stereochemistry , rna , physics , microbiology and biotechnology , genetics , organic chemistry , quantum mechanics , gene
Background/aims: Characterization of skin phosphometabol‐ism in vivo by non‐invasive magnetic resonance spectroscopy (MRS) might allow assessment of ischemic or irradiative damage. Methods: Based on a study of 17 healthy volunteers, we present statistical analyses for intra‐ and inter‐tissue metabolite concentration ratios, as well as for pH and [Mg 2+ ]. Results: Results contrasted steady‐state energy metabolism in skin and muscle, showing lower phosphocreatine/ATP, higher percentage of inorganic phosphate, phosphodiesters and phos‐phomonoesters, and higher pH and [Mg 2+ ] in skin than in muscle. Conclusion: Results were consistent with known skin physiology and structure and suggested an inverse relationship between skin phosphodiester levels and melanin.