Open AccessClinical testing of new drugs for lesional skin diseases such as psoriasis A new delivery system
Author(s) -
Farber Eugene M.,
Wilkinson David I.,
Trozak Daniel J.
Publication year - 1995
Publication title -
skin research and technology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.521
H-Index - 69
eISSN - 1600-0846
pISSN - 0909-752X
DOI - 10.1111/j.1600-0846.1995.tb00013.x
Subject(s) - psoriasis , medicine , erythema , dermatology , delivery system , drug delivery , drug , pharmacology , chemistry , organic chemistry
Background/aims: Efficacy evaluation of new antipsoriatic drugs is difficult in the absence of good animal models. In the experimental treatment of psoriasis plaques, the administered dose of new drugs has to be kept at a minimum for safety reasons. The object is to introduce an extracorporeal system for experimental drug application based on the Alzet osmotic pump. Methods: The system consists of four Alzet pumps from which the drug is delivered intradermally to lesional skin via a 21‐gauge needle. Infusion may be continued for up to 2 weeks. Infusion sites are evaluated clinically by the scoring of scaling, erythema and thickness. Evaluation is also based on scoring of the cardinal microscopic features of psoriasis on a 0 to 19 weighted scale. Results/conclusion: The delivery system was screened using a number of drugs and found useful. The system is cheap and easy to operate.