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Metabolic activity in early tendon repair can be enhanced by intermittent pneumatic compression
Author(s) -
Greve K.,
DomeijArverud E.,
Labruto F.,
Edman G.,
Bring D.,
Nilsson G.,
Ackermann P. W.
Publication year - 2012
Publication title -
scandinavian journal of medicine and science in sports
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.575
H-Index - 115
eISSN - 1600-0838
pISSN - 0905-7188
DOI - 10.1111/j.1600-0838.2012.01475.x
Subject(s) - microdialysis , tendon , metabolite , medicine , glycerol , wound healing , glutamate receptor , adjuvant , surgery , endocrinology , chemistry , biochemistry , central nervous system , receptor
Since A chilles tendon healing is protracted, more knowledge of metabolites known to meet the demands for biosynthesis and proliferation is needed. We hypothesized that essential metabolites, glutamate, glucose, lactate, pyruvate and glycerol, are present and upregulated in healing A chilles tendons. We moreover hypothesized that adjuvant intermittent pneumatic compression ( IPC ), which increases blood flow, upregulates metabolite concentrations. Twenty patients with acute A chilles tendon rupture were recruited, operated, and included. The control group, 15 patients, received plaster cast immobilization, while five patients received adjuvant foot IPC beneath the plaster cast. At 2 weeks postoperatively, microdialysis of the healing and contralateral intact A chilles tendons was followed by quantification of metabolites. Healing compared to intact tendons of the controls exhibited significantly increased concentrations ( mM ) of glutamate (60 ± 14 vs 20 ± 11), lactate (1.15 ± 0.60 vs 0.64 ± 0.35), and pyruvate (81 ± 29 vs 35 ± 25, μM ). Healing tendons of the IPC vs control group displayed higher levels of glutamate (84 ± 15 vs 62 ± 16) and glucose (3.44 ± 0.62 vs 2.62 ± 0.72); ( P < 0.05) and trends toward higher concentrations of pyruvate, lactate, and glycerol ( P < 0.10). The present study demonstrates that early A chilles tendon repair entails and upregulates local essential metabolites. This metabolic response can, during tendon healing with plaster cast immobilization, be promoted by adjuvant IPC.