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Both poor cardiorespiratory and weak muscle fitness are related to a high concentration of oxidized low‐density lipoprotein lipids
Author(s) -
Kosola J.,
Ahotupa M.,
Kyröläinen H.,
Santtila M.,
Vasankari T.
Publication year - 2012
Publication title -
scandinavian journal of medicine and science in sports
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.575
H-Index - 115
eISSN - 1600-0838
pISSN - 0905-7188
DOI - 10.1111/j.1600-0838.2011.01326.x
Subject(s) - vo2 max , cardiorespiratory fitness , medicine , endocrinology , cholesterol , lipoprotein , physical fitness , blood lipids , waist , blood pressure , high density lipoprotein , body mass index , physical therapy , heart rate
Good physical fitness is associated with favorable serum lipids. Oxidized low‐density lipoprotein (ox‐LDL) could be even more atherogenic than serum lipids. We studied the association of ox‐LDL and serum lipids with physical fitness. Healthy young (mean age 25 years) men ( n =846) underwent maximal oxygen uptake (VO 2max ) and muscle fitness index (MFI) tests and completed a leisure‐time physical activity (LTPA) questionnaire. Age (ANCOVA1), age+waist circumference+systolic blood pressure+fasting blood glucose+smoking (ANCOVA3) were used as covariates. The groups with the lowest VO 2max , MFI and LTPA had 23%, 16% and 8% higher concentrations of ox‐LDL than the groups with the highest VO 2max ( P <0.0001), MFI ( P =0.022) and LTPA ( P =0.039) groups, respectively. Subjects with poor fitness (low VO 2max or low MFI) or low LTPA had elevated levels of ox‐LDL/high‐density lipoprotein (HDL)‐cholesterol, total cholesterol, LDL‐cholesterol, triglycerides and a low level of HDL‐cholesterol (ANCOVA1, in all, P <0.05). Furthermore, low VO 2max is associated with a high level of ox‐LDL/HDL‐cholesterol and triglycerides, and with a low level of HDL‐cholesterol (ANCOVA3, in all, P <0.05). Also, subjects with low LTPA had a high ratio of ox‐LDL/HDL‐cholesterol (ANCOVA1, P =0.001). In conclusion, both poor fitness (both low VO 2max and low MFI) and low LTPA are associated with a higher concentration of ox‐LDL lipids and serum lipids, which may indicate a higher risk for atherosclerosis.