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Preserved metabolic reserve capacity in skeletal muscle of post‐infarction heart failure patients
Author(s) -
Slettaløkken G.,
Rehn T. A.,
Munkvik M.,
Rud B.,
SökjerPetersen M.,
Lunde P. K.,
Sjaastad I.,
Sejersted O. M.,
Hallén J.
Publication year - 2012
Publication title -
scandinavian journal of medicine and science in sports
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.575
H-Index - 115
eISSN - 1600-0838
pISSN - 0905-7188
DOI - 10.1111/j.1600-0838.2010.01226.x
Subject(s) - medicine , cardiology , heart failure , skeletal muscle , myocardial infarction , infarction , coronary artery disease
It has been proposed that exercise capacity during whole body exercise in post‐infarction congestive heart failure (CHF) patients is limited by skeletal muscle function. We therefore investigated the balance between cardiopulmonary and muscular metabolic capacity. CHF patients ( n =8) and healthy subjects (HS, n =12) were included. Patients with coronary artery disease (CAD, n =8) were included as a control for medication. All subjects performed a stepwise incremental load test during bicycling (∼24 kg muscle mass), two‐legged knee extensor (2‐KE) exercise (∼4 kg muscle mass) and one‐legged knee extensor (1‐KE) exercise (∼2 kg muscle mass). Peak power and peak pulmonary oxygen uptake (VO 2peak ) increased and muscle‐specific VO 2peak decreased with an increasing muscle mass involved in the exercise. Peak power and VO 2peak were lower for CHF patients than HS, with values for CAD patients falling between CHF patients and HS. During bicycling, all groups utilized 24–29% of the muscle‐specific VO 2peak as measured during 1‐KE exercise, with no difference between the groups. Hence, the muscle metabolic reserve capacity during whole body exercise is not different between CHF patients and HS, indicating that appropriately medicated and stable post‐infarction CHF patients are not more limited by intrinsic skeletal muscle properties during whole body exercise than HS.