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The effect of rowing on endothelial function and insulin action in healthy controls and in patients with type 2 diabetes
Author(s) -
Olsen D. B.,
ScheedeBergdahl C.,
Reving D.,
Boushel R.,
Dela F.
Publication year - 2011
Publication title -
scandinavian journal of medicine and science in sports
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.575
H-Index - 115
eISSN - 1600-0838
pISSN - 0905-7188
DOI - 10.1111/j.1600-0838.2009.01012.x
Subject(s) - medicine , rowing , brachial artery , endocrinology , forearm , insulin , vasodilation , type 2 diabetes , diabetes mellitus , blood pressure , surgery , archaeology , history
Patients with type 2 diabetes (T2DM) have an increased risk for cardiovascular disease. We examined the effects of 8 weeks of home‐based rowing training (heart rate corresponding to 65–70% of VO 2 peak ) on endothelial function and glucose clearance (local and systemic effects) in male subjects with T2DM ( n =9) and matched controls ( n =8). Before and after training (30 min every other day), all subjects underwent sequential graded brachial artery infusions of non‐insulin vasodilators (acetylcholine; sodium nitroprusside; adenosine). Forearm blood flow was improved by training in controls (without and with insulin: P =0.003 and 0.05, respectively) but not in subjects with T2DM. Likewise, whole body glucose clearance increased in response to training in controls ( P =0.05) but not in T2DM. However, in both groups, the capacity for local forearm glucose extraction (controls: P =0.001; T2DM: P =0.002) and clearance (controls: P <0.001; T2DM: P =0.01) were positively affected by exercise. While the subjects with T2DM did not respond to the same degree as controls to 8 weeks of home‐based exercise, there are clear benefits as illustrated by improvements in local glucose disposal. Training of higher intensity or duration may be required in order to elicit a response similar to controls.