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Do PPARGC1A and PPARα polymorphisms influence sprint or endurance phenotypes?
Author(s) -
Ey N.,
Meckel Y.,
Sagiv M.,
Yamin C.,
Amir R.,
Sagiv M.,
Goldhammer E.,
Duarte J. A.,
Oliveira J.
Publication year - 2010
Publication title -
scandinavian journal of medicine and science in sports
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.575
H-Index - 115
eISSN - 1600-0838
pISSN - 0905-7188
DOI - 10.1111/j.1600-0838.2009.00930.x
Subject(s) - athletes , sprint , endurance training , genotype , ppargc1a , medicine , endocrinology , allele , allele frequency , polymorphism (computer science) , biology , physical therapy , genetics , gene , coactivator , transcription factor
Functional Gly482Ser (rs8192678) and G/C (rs4253778) polymorphisms in the Peroxisome proliferator‐activated receptor γ coactivator1 ( PPARGC1A ) and Peroxisome proliferator‐activated receptor α ( PPARα ) genes, respectively, have been associated with mRNA and protein activity. The aim of this study was to determine their frequency distribution among 155 Israeli athletes (endurance athletes and sprinters) and 240 healthy controls. Results showed that there was a significant difference in PPARGC1A Ser482Gly polymorphism genotype frequencies between endurance athletes and sprinters ( P =0.005) as well as between endurance athletes and controls ( P =0.0003). However, the sprinters' genotype and allele frequencies were similar to that of the control group. A significantly lower proportion of PPARGC1A Ser482 allele (0.25) was noted for the endurance athletes compared with controls (0.43, P =0.0001). Endurance athletes showed a trend of a higher yet a not significant proportion of the PPARα GG genotype compared with sprinters ( P =0.051). As we compared between the subgroups of top‐level endurance athletes and top‐level sprinters, as well as between those of top‐level and national‐level endurance athletes, we reached more prominent results. In conclusion, our data indicate that a lower frequency of the Ser482 allele and possibly a higher frequency of the GG genotype are associated with increased endurance performance ability.